BAIT
PPP3CA
CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme
GO Process (10)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [TAS]
- calcineurin-NFAT signaling cascade [IDA]
- cellular response to drug [IDA]
- dephosphorylation [TAS]
- innate immune response [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein dephosphorylation [IDA, NAS]
- response to calcium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcineurin complex [IDA, NAS]
- cytoplasm [IDA]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
Homo sapiens
PREY
CABIN1
CAIN, PPP3IN
calcineurin binding protein 1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.
Calcineurin plays a pivotal role in the T cell receptor (TCR)-mediated signal transduction pathway and serves as a common target for the immunosuppressants FK506 and cyclosporin A. We report the identification of a novel endogenous calcineurin binding protein named Cabin 1 that inhibits calcineurin-mediated signal transduction. The interaction between Cabin 1 and calcineurin is dependent on PKC activation. Overexpression of ... [more]
Immunity Jun. 01, 1998; 8(6);703-11 [Pubmed: 9655484]
Throughput
- Low Throughput
Curated By
- BioGRID