BAIT
TEC
PSCTK4
tec protein tyrosine kinase
GO Process (13)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA]
- cell differentiation [IBA]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IDA]
- peptidyl-tyrosine autophosphorylation [IBA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of platelet activation [IDA]
- tissue regeneration [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GNA13
G13
guanine nucleotide binding protein (G protein), alpha 13
GO Process (7)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.
Heterotrimeric G proteins, G12 and G13, have been shown to transduce signals from G protein-coupled receptors to activate Rho GTPase in cells. Recently, we identified p115RhoGEF, one of the guanine nucleotide exchange factors (GEFs) for Rho, as a direct link between Galpha13 and Rho [Kozasa, T., et al. (1998) Science 280, 2109-2111; Hart, M. J., et al. (1998) Science 280, ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jan. 21, 2003; 100(2);733-8 [Pubmed: 12515866]
Throughput
- Low Throughput
Additional Notes
- triple mutant
Curated By
- BioGRID