BAIT
CCL5
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
chemokine (C-C motif) ligand 5
GO Process (62)
GO Function (14)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- MAPK cascade [IMP]
- activation of phospholipase D activity [IDA]
- calcium ion transport [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular protein complex assembly [IDA]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemokine-mediated signaling pathway [IDA, TAS]
- chemotaxis [NAS]
- dendritic cell chemotaxis [TAS]
- eosinophil chemotaxis [IDA]
- exocytosis [IDA]
- inflammatory response [IDA]
- leukocyte cell-cell adhesion [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [TAS]
- monocyte chemotaxis [IC]
- negative regulation by host of viral transcription [IDA]
- negative regulation of G-protein coupled receptor protein signaling pathway [IDA]
- negative regulation of T cell apoptotic process [IDA]
- negative regulation of chemokine-mediated signaling pathway [IDA]
- negative regulation of viral genome replication [IDA]
- neutrophil activation [IDA]
- positive chemotaxis [IDA]
- positive regulation of JAK-STAT cascade [TAS]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of T cell chemotaxis [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of activation of JAK2 kinase activity [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-cell adhesion mediated by integrin [IDA]
- positive regulation of cellular biosynthetic process [IDA]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of innate immune response [TAS]
- positive regulation of macrophage chemotaxis [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of phosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of translational initiation [NAS]
- positive regulation of tyrosine phosphorylation of STAT protein [IDA]
- positive regulation of viral genome replication [TAS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of T cell activation [IDA]
- regulation of chronic inflammatory response [TAS]
- regulation of insulin secretion [IDA]
- regulation of neuron death [IDA]
- response to toxic substance [IDA]
- response to virus [TAS]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
- CCR1 chemokine receptor binding [IDA, IPI, TAS]
- CCR4 chemokine receptor binding [TAS]
- CCR5 chemokine receptor binding [IPI]
- chemoattractant activity [IDA]
- chemokine activity [IDA, NAS]
- chemokine receptor antagonist activity [IDA]
- chemokine receptor binding [IPI]
- phosphatidylinositol phospholipase C activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase activity [IDA]
- protein self-association [IDA]
- receptor signaling protein tyrosine kinase activator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
CCL2
GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF
chemokine (C-C motif) ligand 2
GO Process (41)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]
- JAK-STAT cascade [TAS]
- MAPK cascade [IMP]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- angiogenesis [TAS]
- astrocyte cell migration [IDA]
- cell adhesion [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular homeostasis [TAS]
- cellular protein metabolic process [TAS]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to interferon-gamma [IEP, ISS]
- cellular response to interleukin-1 [IEP, ISS]
- cellular response to lipopolysaccharide [ISS]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP, ISS]
- chemotaxis [TAS]
- cytokine-mediated signaling pathway [IDA]
- cytoskeleton organization [IDA]
- endoplasmic reticulum unfolded protein response [TAS]
- helper T cell extravasation [ISS]
- humoral immune response [TAS]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- macrophage chemotaxis [IDA]
- monocyte chemotaxis [IDA]
- negative regulation of glial cell apoptotic process [IDA]
- negative regulation of natural killer cell chemotaxis [IDA]
- negative regulation of neuron apoptotic process [IDA]
- organ morphogenesis [TAS]
- positive regulation of T cell activation [ISS]
- positive regulation of apoptotic cell clearance [ISS]
- positive regulation of calcium ion import [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [TAS]
- regulation of cell shape [IDA]
- response to bacterium [IEP]
- signal transduction [NAS]
- viral genome replication [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Chemokine receptor homo- or heterodimerization activates distinct signaling pathways.
Chemokine receptors of both the CC and CXC families have been demonstrated to undergo a ligand-mediated homodimerization process required for Ca2+ flux and chemotaxis. We show that, in the chemokine response, heterodimerization is also permitted between given receptor pairs, specifically between CCR2 and CCR5. This has functional consequences, as the CCR2 and CCR5 ligands monocyte chemotactic protein-1 (MCP-1) and RANTES ... [more]
EMBO J. May. 15, 2001; 20(10);2497-507 [Pubmed: 11350939]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID