An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.

Wang H, Brautigan DL

Protein kinases and protein phosphatases exert coordinated control over many essential cellular processes. Here, we describe the cloning and characterization of a novel human transmembrane protein KPI-2 (Kinase/Phosphatase/Inhibitor-2) that was identified by yeast two-hybrid using protein phosphatase inhibitor-2 (Inh2) as bait. KPI-2 mRNA was predominantly expressed in skeletal muscle. KPI-2 is a 1503-residue protein with two predicted transmembrane helices at ... [more]

J. Biol. Chem. Dec. 20, 2002; 277(51);49605-12 [Pubmed: 12393858]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

LMTK2

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [NAS]myosin VI binding [IPI]protein binding [IPI]protein phosphatase inhibitor activity [IDA]protein serine/threonine kinase activity [IDA]

Gene Ontology Cellular Component