BAIT
PITX2
ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
paired-like homeodomain 2
GO Process (16)
GO Function (13)
GO Component (3)
Gene Ontology Biological Process
- camera-type eye development [IMP]
- cardiac neural crest cell migration involved in outflow tract morphogenesis [ISS]
- cell proliferation involved in outflow tract morphogenesis [ISS]
- deltoid tuberosity development [IMP]
- determination of left/right symmetry [ISS]
- hair cell differentiation [IC]
- iris morphogenesis [IMP]
- left/right axis specification [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- odontogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prolactin secreting cell differentiation [TAS]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- somatotropin secreting cell differentiation [TAS]
- spleen development [ISS]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- ribonucleoprotein complex binding [IC]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
- identical protein binding [IPI]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- ribonucleoprotein complex binding [IC]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
MSX2
CRS2, FPP, HOX8, MSH, PFM, PFM1
msh homeobox 2
GO Process (5)
GO Function (4)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development.
The transcriptional mechanisms underlying tooth development are only beginning to be understood. Pitx2, a bicoid-like homeodomain transcription factor, is the first transcriptional marker observed during tooth development. Because Pitx2, Msx2, and Dlx2 are expressed in the dental epithelium, we examined the transcriptional activity of PITX2 in concert with Msx2 and the Dlx2 promoter. PITX2 activated while Msx2 unexpectedly repressed transcription ... [more]
Gene Expr. Jan. 05, 2002; 9(6);265-81 [Pubmed: 11763998]
Throughput
- Low Throughput
Curated By
- BioGRID