BAIT
LYST
CHS, CHS1
lysosomal trafficking regulator
GO Process (9)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- defense response to bacterium [ISS]
- defense response to protozoan [ISS]
- defense response to virus [ISS]
- endosome to lysosome transport via multivesicular body sorting pathway [IMP]
- leukocyte chemotaxis [ISS]
- mast cell secretory granule organization [ISS]
- melanosome organization [ISS]
- natural killer cell mediated cytotoxicity [IMP]
- pigmentation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HNRNPM
CEAR, HNRNPM4, HNRPM, HNRPM4, HTGR1, NAGR1, hnRNP M
heterogeneous nuclear ribonucleoprotein M
GO Process (4)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.
BACKGROUND:Chediak-Higashi syndrome (CHS) is an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. CHS results from mutations in the lysosomal trafficking regulator (LYST) gene, which encodes a 425-kD cytoplasmic protein of unknown function. The goal of this study was to identify proteins that interact with LYST as a first step in understanding how LYST modulates lysosomal exocytosis. ... [more]
Mol. Med. Jan. 01, 2002; 8(1);56-64 [Pubmed: 11984006]
Throughput
- Low Throughput
Curated By
- BioGRID