Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.

Keep NH, Winder SJ, Moores CA, Walke S, Norwood FL, Kendrick-Jones J

BACKGROUND: Utrophin is a large multidomain protein that belongs to a superfamily of actin-binding proteins, which includes dystrophin, alpha-actinin, beta-spectrin, fimbrin, filamin and plectin. All the members of this family contain a common actin-binding region at their N termini and perform a wide variety of roles associated with the actin cytoskeleton. Utrophin is the autosomal homologue of dystrophin, the protein ... [more]

Structure Dec. 15, 1999; 7(12);1539-46 [Pubmed: 10647184]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

UTRN

Gene Ontology Biological Process

Gene Ontology Molecular Function

actin binding [IDA]integrin binding [IPI]protein binding [IPI]protein kinase binding [IPI]vinculin binding [IPI]

Gene Ontology Cellular Component