BAIT
TAS1R3
T1R3
taste receptor, type 1, member 3
GO Process (4)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HYAL2
LUCA2
hyaluronoglucosaminidase 2
GO Process (33)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cellular response to UV-B [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to interleukin-1 [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- cellular response to tumor necrosis factor [IEP]
- fusion of virus membrane with host plasma membrane [IDA]
- glycosaminoglycan catabolic process [IDA]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [TAS]
- kidney development [ISS]
- monocyte activation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of fibroblast migration [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of protein tyrosine kinase activity [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [ISS]
- positive regulation of inflammatory response [IDA]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of protein import into nucleus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of urine volume [ISS]
- renal water absorption [ISS]
- response to antibiotic [IEP]
- response to reactive oxygen species [IDA]
- response to virus [IDA]
- small molecule metabolic process [TAS]
- transformation of host cell by virus [IDA, ISS]
- viral entry into host cell [ISS]
Gene Ontology Molecular Function- enzyme binding [IPI]
- hyaluronic acid binding [IDA]
- hyaluronoglucuronidase activity [IDA]
- hyalurononglucosaminidase activity [IDA, TAS]
- protein binding [IPI]
- receptor signaling protein tyrosine kinase inhibitor activity [IDA]
- receptor tyrosine kinase binding [IPI]
- transforming growth factor beta binding [ISS]
- virus receptor activity [IDA]
- enzyme binding [IPI]
- hyaluronic acid binding [IDA]
- hyaluronoglucuronidase activity [IDA]
- hyalurononglucosaminidase activity [IDA, TAS]
- protein binding [IPI]
- receptor signaling protein tyrosine kinase inhibitor activity [IDA]
- receptor tyrosine kinase binding [IPI]
- transforming growth factor beta binding [ISS]
- virus receptor activity [IDA]
Gene Ontology Cellular Component
- Golgi membrane [ISS]
- RNA polymerase II transcription factor complex [ISS]
- anchored component of external side of plasma membrane [IDA]
- anchored component of plasma membrane [IDA]
- apical plasma membrane [IDA]
- cell surface [IDA, ISS]
- cytoplasm [IDA]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [IDA]
- endocytic vesicle [IDA]
- endoplasmic reticulum [NAS]
- lysosome [IDA]
- membrane raft [IDA]
- microvillus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [TAS]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.930627898 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.930627898, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID