HTR3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ABCA7
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- apolipoprotein A-I-mediated signaling pathway [IDA]
- cholesterol efflux [IDA]
- high-density lipoprotein particle assembly [IDA]
- memory [ISS]
- negative regulation of ATPase activity [IDA]
- negative regulation of amyloid precursor protein biosynthetic process [ISS]
- negative regulation of beta-amyloid formation [ISS]
- peptide cross-linking [ISS]
- phospholipid efflux [IDA]
- phospholipid scrambling [IDA]
- positive regulation of ATPase activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of beta-amyloid clearance [ISS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of engulfment of apoptotic cell [ISS]
- positive regulation of phagocytosis [ISS]
- positive regulation of phospholipid efflux [ISS]
- protein localization to nucleus [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.999993003 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999993003, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HTR3A ABCA7 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2222303 |
Curated By
- BioGRID