BAIT
AMHR2
AMHR, MISR2, MISRII, MRII
anti-Mullerian hormone receptor, type II
GO Process (3)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
BBS4
Bardet-Biedl syndrome 4
GO Process (33)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- adult behavior [ISS]
- brain morphogenesis [ISS]
- centrosome organization [IMP]
- cerebral cortex development [ISS]
- cilium assembly [ISS]
- cilium morphogenesis [ISS]
- dendrite development [ISS]
- fat cell differentiation [ISS]
- heart looping [ISS]
- hippocampus development [ISS]
- intracellular transport [ISS]
- maintenance of protein location in nucleus [IGI]
- melanosome transport [ISS]
- metabolic process [IMP]
- microtubule anchoring at centrosome [IMP]
- microtubule cytoskeleton organization [ISS]
- mitotic cytokinesis [IMP]
- negative regulation of appetite by leptin-mediated signaling pathway [ISS]
- neural tube closure [ISS]
- nonmotile primary cilium assembly [ISS]
- photoreceptor cell maintenance [ISS]
- positive regulation of cilium assembly [ISS]
- protein localization to centrosome [IMP]
- protein localization to organelle [ISS]
- regulation of cilium beat frequency involved in ciliary motility [ISS]
- regulation of cytokinesis [IMP]
- regulation of lipid metabolic process [ISS]
- retina homeostasis [ISS]
- retinal rod cell development [ISS]
- sensory perception of smell [ISS]
- sensory processing [TAS]
- spermatid development [ISS]
- striatum development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999999349 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999999349, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID