PVRL3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
INPP5K
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- actin cytoskeleton organization [NAS]
- cellular response to cAMP [ISS]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to hormone stimulus [ISS]
- cellular response to insulin stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- dephosphorylation [IDA, IMP]
- glucose homeostasis [ISS]
- inositol phosphate dephosphorylation [IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of calcium ion transport [IDA]
- negative regulation of dephosphorylation [ISS]
- negative regulation of glucose transport [IDA]
- negative regulation of glycogen (starch) synthase activity [ISS]
- negative regulation of glycogen biosynthetic process [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of peptidyl-serine phosphorylation [IDA]
- negative regulation of peptidyl-threonine phosphorylation [IDA]
- negative regulation of protein kinase B signaling [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein targeting to membrane [IDA]
- negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [IDA]
- negative regulation of stress fiber assembly [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA]
- phospholipid metabolic process [TAS]
- positive regulation of renal water transport [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- positive regulation of urine volume [ISS]
- protein targeting to plasma membrane [ISS]
- regulation of glycogen biosynthetic process [ISS]
- ruffle assembly [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- inositol bisphosphate phosphatase activity [IDA]
- inositol trisphosphate phosphatase activity [IDA]
- lipid phosphatase activity [NAS]
- phosphatidylinositol phosphate 5-phosphatase activity [IMP]
- phosphatidylinositol trisphosphate phosphatase activity [IDA]
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- protein binding [IPI]
- vasopressin receptor activity [ISS]
- inositol bisphosphate phosphatase activity [IDA]
- inositol trisphosphate phosphatase activity [IDA]
- lipid phosphatase activity [NAS]
- phosphatidylinositol phosphate 5-phosphatase activity [IMP]
- phosphatidylinositol trisphosphate phosphatase activity [IDA]
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity [IDA]
- protein binding [IPI]
- vasopressin receptor activity [ISS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.76115222 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.76115222, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PVRL3 INPP5K | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9923 | BioGRID | 1187760 | |
PVRL3 INPP5K | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8348 | BioGRID | 2265554 |
Curated By
- BioGRID