CRH
Gene Ontology Biological Process
- female pregnancy [IDA]
- inflammatory response [IDA]
- learning or memory [TAS]
- negative regulation of circadian sleep/wake cycle, REM sleep [NAS]
- parturition [TAS]
- positive regulation of circadian sleep/wake cycle, wakefulness [NAS]
- positive regulation of cortisol secretion [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IDA]
- signal transduction [TAS]
- synaptic transmission [TAS]
- synaptic transmission, dopaminergic [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CRHR1
Gene Ontology Biological Process
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [IDA]
- adrenal gland development [ISO]
- behavioral response to cocaine [IMP]
- behavioral response to ethanol [ISO]
- behavioral response to pain [IMP]
- cellular response to corticotropin-releasing hormone stimulus [ISO, ISS]
- corticotropin secretion [ISO, ISS]
- epithelial cell differentiation [IMP]
- fear response [ISO]
- general adaptation syndrome, behavioral process [ISO]
- hormone-mediated signaling pathway [IDA]
- hypothalamus development [IEP]
- locomotory exploration behavior [IMP]
- long-term synaptic potentiation [IMP]
- memory [IMP]
- negative regulation of epinephrine secretion [IMP]
- negative regulation of feeding behavior [IMP]
- negative regulation of neuron death [IMP]
- negative regulation of voltage-gated calcium channel activity [ISO]
- neuropeptide signaling pathway [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO, ISS]
- positive regulation of cAMP biosynthetic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IMP]
- positive regulation of mast cell degranulation [IMP]
- regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO]
- regulation of corticosterone secretion [ISO, ISS]
- regulation of synaptic plasticity [IMP]
- response to electrical stimulus [IMP]
- response to hypoxia [IMP]
- response to immobilization stress [IEP]
- visual learning [IMP]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, TAS]
- corticotrophin-releasing factor receptor activity [ISO, ISS]
- corticotropin-releasing hormone binding [IDA]
- corticotropin-releasing hormone receptor activity [IDA]
- peptide binding [IDA, IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, TAS]
- corticotrophin-releasing factor receptor activity [ISO, ISS]
- corticotropin-releasing hormone binding [IDA]
- corticotropin-releasing hormone receptor activity [IDA]
- peptide binding [IDA, IPI]
- protein binding [IPI]
- protein complex binding [IPI]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin.
The binding of the novel radioligand, [3H]-rat urocortin to homogenates of rat cerebellum and homogenates of cells stably transfected with the human CRF1, rat CRF2alpha and rat CRF2beta receptors was examined. In each case, specific reversible high affinity binding was observed (K[d]s between 0.18 and 0.31 nM). The density of sites was relatively low in the cerebellum (9 fmol/mg tissue) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID