LGALS3
Gene Ontology Biological Process
- eosinophil chemotaxis [IDA]
- epithelial cell differentiation [IEP]
- innate immune response [TAS]
- macrophage chemotaxis [IDA]
- monocyte chemotaxis [IDA]
- mononuclear cell migration [IDA]
- negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell [ISS]
- negative regulation of T cell receptor signaling pathway [ISS]
- negative regulation of endocytosis [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of immunological synapse formation [ISS]
- neutrophil chemotaxis [IDA]
- positive chemotaxis [IDA]
- positive regulation of calcium ion import [IDA]
- positive regulation of mononuclear cell migration [IDA]
- regulation of T cell apoptotic process [IDA]
- regulation of T cell proliferation [IMP]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ENPP4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.9998525 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.9998525, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LGALS3 ENPP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9997 | BioGRID | 1176731 | |
| LGALS3 ENPP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 2227969 |
Curated By
- BioGRID