BAIT
GPIHBP1
GPI-HBP1, HYPL1D
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GO Process (11)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- cholesterol homeostasis [ISS]
- intracellular protein transport [ISS]
- positive regulation of chylomicron remnant clearance [ISS]
- positive regulation of lipoprotein lipase activity [IMP]
- protein import [ISS]
- protein localization to cell surface [ISS]
- protein stabilization [ISS]
- protein transmembrane transport [ISS]
- response to heparin [IMP]
- transcytosis [ISS]
- triglyceride homeostasis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NLGN1
NL1
neuroligin 1
GO Process (36)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cytoskeletal matrix organization at active zone [ISS]
- establishment of protein localization [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- metabolic process [IBA]
- nervous system development [ISS]
- neurexin clustering [ISS]
- neuron cell-cell adhesion [ISS, TAS]
- neuronal signal transduction [TAS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of intracellular signal transduction [ISS]
- positive regulation of ruffle assembly [ISS]
- positive regulation of synapse assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- positive regulation of synaptic vesicle endocytosis [ISS]
- positive regulation of synaptic vesicle exocytosis [ISS]
- postsynaptic density protein 95 clustering [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein homooligomerization [ISS]
- protein localization to synapse [ISS]
- protein targeting [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of neuron differentiation [ISS]
- regulation of synaptic transmission [IBA]
- synapse assembly [IBA, ISS]
- synaptic vesicle clustering [ISS]
- synaptic vesicle targeting [ISS]
- terminal button organization [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.984279619 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.984279619, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID