BAIT
AHI1
AHI-1, JBTS3, ORF1, dJ71N10.1, RP1-32B1.2
Abelson helper integration site 1
GO Process (23)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
- Kupffer's vesicle development [ISS]
- cellular protein localization [ISS]
- central nervous system development [ISS]
- cilium assembly [ISS]
- cilium morphogenesis [ISS]
- cloaca development [ISS]
- heart looping [ISS]
- hindbrain development [ISS]
- left/right axis specification [ISS]
- morphogenesis of a polarized epithelium [ISS]
- negative regulation of apoptotic process [ISS]
- otic vesicle development [ISS]
- photoreceptor cell outer segment organization [ISS]
- positive regulation of polarized epithelial cell differentiation [ISS]
- positive regulation of receptor internalization [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- pronephric duct morphogenesis [ISS]
- pronephric nephron tubule morphogenesis [ISS]
- regulation of behavior [ISS]
- retina layer formation [ISS]
- specification of axis polarity [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISS]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ALDH5A1
SSADH, SSDH
aldehyde dehydrogenase 5 family, member A1
GO Process (16)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- acetate metabolic process [ISS]
- central nervous system development [IMP]
- galactosylceramide metabolic process [ISS]
- gamma-aminobutyric acid catabolic process [IDA, IMP]
- glucose metabolic process [ISS]
- glutamate metabolic process [ISS]
- glutamine metabolic process [ISS]
- glutathione metabolic process [ISS]
- glycerophospholipid metabolic process [ISS]
- neurotransmitter catabolic process [ISS]
- neurotransmitter secretion [TAS]
- protein homotetramerization [IDA]
- respiratory electron transport chain [ISS]
- short-chain fatty acid metabolic process [ISS]
- succinate metabolic process [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999746737 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999746737, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID