TP63
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IBA]
- establishment of skin barrier [ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of cellular senescence [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell cycle G1/S phase transition [IMP]
- positive regulation of fibroblast apoptotic process [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein homotetramerization [IPI]
- regulation of epidermal cell division [ISS]
- regulation of neuron apoptotic process [IBA]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
Gene Ontology Molecular Function
RPH3A
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent phospholipid binding [ISS]
- inositol 1,4,5 trisphosphate binding [ISS]
- phosphate ion binding [ISS]
- phosphatidylinositol phosphate binding [TAS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- selenium binding [ISS]
- zinc ion binding [ISS]
- calcium ion binding [ISS]
- calcium-dependent phospholipid binding [ISS]
- inositol 1,4,5 trisphosphate binding [ISS]
- phosphate ion binding [ISS]
- phosphatidylinositol phosphate binding [TAS]
- phosphatidylinositol-4,5-bisphosphate binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- selenium binding [ISS]
- zinc ion binding [ISS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.999964801 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999964801, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TP63 RPH3A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9998 | BioGRID | 2228450 |
Curated By
- BioGRID