BAIT
LY6H
NMLY6
lymphocyte antigen 6 complex, locus H
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
TGFB2
LDS4, TGF-beta2
transforming growth factor, beta 2
GO Process (72)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- SMAD protein import into nucleus [IDA]
- SMAD protein signal transduction [IBA]
- activation of protein kinase activity [IDA]
- angiogenesis [TAS]
- blood coagulation [TAS]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [IDA]
- cardioblast differentiation [IDA]
- catagen [IDA]
- cell cycle arrest [IDA]
- cell death [IDA]
- cell migration [IDA]
- cell morphogenesis [IDA]
- cell proliferation [TAS]
- cell-cell junction organization [IDA]
- cell-cell signaling [TAS]
- collagen fibril organization [IDA]
- dopamine biosynthetic process [ISS]
- embryo development [TAS]
- embryonic digestive tract development [IEP]
- epithelial to mesenchymal transition [IDA, TAS]
- extracellular matrix organization [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- eye development [IDA]
- generation of neurons [TAS]
- glial cell migration [IDA]
- hair follicle development [IDA, ISS]
- hair follicle morphogenesis [ISS]
- heart development [IDA]
- heart morphogenesis [IDA]
- hemopoiesis [ISS]
- negative regulation of alkaline phosphatase activity [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of immune response [TAS]
- negative regulation of macrophage cytokine production [IDA]
- neuron development [ISS]
- neutrophil chemotaxis [ISS, TAS]
- odontogenesis [NAS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of cardioblast differentiation [IDA]
- positive regulation of catagen [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell cycle [ISS]
- positive regulation of cell growth [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of heart contraction [IDA]
- positive regulation of immune response [ISS]
- positive regulation of integrin biosynthetic process [IDA]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of ossification [IEP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of stress-activated MAPK cascade [IDA]
- protein phosphorylation [IDA]
- regulation of transforming growth factor beta2 production [IMP]
- response to drug [IDA]
- response to hypoxia [IMP]
- response to progesterone [IDA]
- response to wounding [IEP]
- salivary gland morphogenesis [IEP]
- signal transduction by phosphorylation [IDA]
- somatic stem cell division [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- uterine wall breakdown [TAS]
- wound healing [ISS]
Gene Ontology Molecular Function- beta-amyloid binding [IDA]
- cytokine activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- receptor binding [IMP]
- receptor signaling protein serine/threonine kinase activity [IDA]
- transforming growth factor beta receptor binding [IDA]
- type II transforming growth factor beta receptor binding [IDA, IPI]
- beta-amyloid binding [IDA]
- cytokine activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [TAS]
- protein homodimerization activity [IDA]
- receptor binding [IMP]
- receptor signaling protein serine/threonine kinase activity [IDA]
- transforming growth factor beta receptor binding [IDA]
- type II transforming growth factor beta receptor binding [IDA, IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.760767387 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.760767387, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID