NOTCH2
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [TAS]
- apoptotic process [TAS]
- atrial septum morphogenesis [IMP]
- bone remodeling [IMP]
- cell cycle arrest [IDA]
- cell fate determination [TAS]
- cell growth [IDA]
- gene expression [TAS]
- hemopoiesis [TAS]
- intracellular receptor signaling pathway [TAS]
- multicellular organismal development [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell proliferation [IDA]
- nervous system development [NAS]
- organ morphogenesis [IEP]
- positive regulation of Ras protein signal transduction [IDA]
- pulmonary valve morphogenesis [IMP]
- regulation of transcription, DNA-templated [TAS]
- stem cell maintenance [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLI4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.999841884 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999841884, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GLI4 NOTCH2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.6751 | BioGRID | 3275035 |
Curated By
- BioGRID