BAIT
RAB17
RAB17, member RAS oncogene family
GO Process (14)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- GTP catabolic process [IBA, IDA]
- Rab protein signal transduction [IBA]
- cilium assembly [IMP]
- endocytic recycling [IBA, ISS]
- establishment of melanosome localization [ISS]
- filopodium assembly [ISS]
- immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [ISS]
- intracellular protein transport [IBA]
- melanosome transport [ISS]
- regulation of dendrite development [ISS]
- regulation of endocytosis [IBA]
- regulation of filopodium assembly [IBA, ISS]
- regulation of synapse assembly [ISS]
- transcytosis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [ISS]
- basolateral plasma membrane [ISS]
- dendrite [ISS]
- early endosome [IBA]
- endocytic vesicle [IBA, IDA]
- extracellular vesicular exosome [IDA]
- intracellular [IDA]
- melanosome [ISS]
- neuronal cell body [ISS]
- plasma membrane [IBA]
- recycling endosome [ISS]
- recycling endosome membrane [IBA, ISS]
Homo sapiens
PREY
DBT
BCATE2, BCKAD-E2, BCKADE2, E2, E2B, RP11-305E17.3
dihydrolipoamide branched chain transacylase E2
GO Process (3)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.781046998 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.781046998, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID