BAIT
ESRRG
ERR3, ERRgamma, NR3B3
estrogen-related receptor gamma
GO Process (4)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PROX1
prospero homeobox 1
GO Process (47)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
- aorta smooth muscle tissue morphogenesis [ISS]
- atrial cardiac muscle tissue morphogenesis [ISS]
- brain development [IEP]
- cerebellar granule cell differentiation [ISS]
- dentate gyrus development [ISS]
- dorsal spinal cord development [ISS]
- embryonic retina morphogenesis in camera-type eye [IEP]
- endocardium formation [ISS]
- hepatocyte differentiation [IEP]
- kidney development [IEP]
- lens development in camera-type eye [IEP]
- lens fiber cell morphogenesis [IEP]
- liver development [IEP]
- lung development [IEP]
- lymphangiogenesis [IDA]
- lymphatic endothelial cell differentiation [IDA]
- negative regulation of bile acid biosynthetic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral genome replication [IDA]
- neural tube development [ISS]
- neuronal stem cell maintenance [ISS]
- olfactory placode formation [ISS]
- optic placode formation involved in camera-type eye formation [ISS]
- otic placode formation [ISS]
- pancreas development [IEP]
- positive regulation of cell cycle [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of forebrain neuron differentiation [ISS]
- positive regulation of heart growth [ISS]
- positive regulation of neural precursor cell proliferation [ISS]
- positive regulation of sarcomere organization [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of circadian rhythm [IMP]
- regulation of gene expression [IDA]
- regulation of transcription involved in lymphatic endothelial cell fate commitment [IMP]
- retina morphogenesis in camera-type eye [ISS]
- skeletal muscle thin filament assembly [ISS]
- venous blood vessel morphogenesis [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular cardiac myofibril assembly [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DBD domain binding [IPI]
- DNA binding [IMP]
- LBD domain binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IC]
- transcription corepressor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DBD domain binding [IPI]
- DNA binding [IMP]
- LBD domain binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IC]
- transcription corepressor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.998766534 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.998766534, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ESRRG PROX1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID