BAIT
AQP9
AQP-9, HsT17287, SSC1
aquaporin 9
GO Process (21)
GO Function (10)
GO Component (4)
Gene Ontology Biological Process
- amine transport [IDA]
- carboxylic acid transport [TAS]
- cellular response to cAMP [IEP]
- cellular water homeostasis [IBA]
- excretion [TAS]
- glycerol transport [TAS]
- immune response [TAS]
- ion transmembrane transport [IBA]
- metabolic process [TAS]
- polyol transport [IDA]
- purine nucleobase transport [IDA]
- pyrimidine nucleobase transport [IDA]
- pyrimidine-containing compound transmembrane transport [IDA]
- response to mercury ion [IDA]
- response to organic substance [IDA]
- response to osmotic stress [TAS]
- transmembrane transport [TAS]
- transport [TAS]
- urea transmembrane transport [IBA]
- water homeostasis [NAS]
- water transport [IDA, TAS]
Gene Ontology Molecular Function- amine transmembrane transporter activity [TAS]
- carboxylic acid transmembrane transporter activity [TAS]
- glycerol channel activity [EXP, IBA]
- polyol transmembrane transporter activity [TAS]
- porin activity [NAS]
- purine nucleobase transmembrane transporter activity [IDA]
- pyrimidine nucleobase transmembrane transporter activity [IDA]
- urea transmembrane transporter activity [IBA]
- water channel activity [IDA]
- water transmembrane transporter activity [TAS]
- amine transmembrane transporter activity [TAS]
- carboxylic acid transmembrane transporter activity [TAS]
- glycerol channel activity [EXP, IBA]
- polyol transmembrane transporter activity [TAS]
- porin activity [NAS]
- purine nucleobase transmembrane transporter activity [IDA]
- pyrimidine nucleobase transmembrane transporter activity [IDA]
- urea transmembrane transporter activity [IBA]
- water channel activity [IDA]
- water transmembrane transporter activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
HGS
HRS
hepatocyte growth factor-regulated tyrosine kinase substrate
GO Process (13)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.970881122 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.970881122, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID