BAIT
FGF8
AIGF, FGF-8, HBGF-8, HH6, KAL6
fibroblast growth factor 8 (androgen-induced)
GO Process (20)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- anatomical structure morphogenesis [NAS]
- bone development [IMP]
- dopaminergic neuron differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- fibroblast growth factor receptor signaling pathway [IGI, TAS]
- gastrulation [NAS]
- gonad development [IMP]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- mesonephros development [IEP]
- metanephros development [IEP]
- negative regulation of cardiac muscle tissue development [IMP]
- neuroepithelial cell differentiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis [IEP]
- outflow tract septum morphogenesis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PURA
PUR-ALPHA, PUR1, PURALPHA, hCG_45299
purine-rich element binding protein A
GO Process (4)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.795862601 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.795862601, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID