FAM19A4
GPLD1
Gene Ontology Biological Process
- GPI anchor release [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to calcium ion [IDA]
- cellular response to cholesterol [IMP]
- cellular response to drug [IDA]
- cellular response to insulin stimulus [IDA]
- cellular response to pH [IDA]
- cellular response to triglyceride [IMP]
- chondrocyte differentiation [ISS]
- complement receptor mediated signaling pathway [IDA]
- hematopoietic stem cell migration [TAS]
- hematopoietic stem cell migration to bone marrow [TAS]
- insulin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of triglyceride catabolic process [ISS]
- ossification [ISS]
- phosphatidylcholine metabolic process [ISS, TAS]
- positive regulation of alkaline phosphatase activity [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of cytolysis [IDA]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of glucose metabolic process [ISS]
- positive regulation of high-density lipoprotein particle clearance [ISS]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of secretion [ISS]
- positive regulation of triglyceride biosynthetic process [ISS]
- regulation of cellular response to insulin stimulus [IDA]
- response to glucose [IDA]
- transepithelial transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.993405949 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.993405949, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FAM19A4 GPLD1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.996 | BioGRID | 2237050 |
Curated By
- BioGRID