TGFBR2
Gene Ontology Biological Process
- activation of protein kinase activity [ISS]
- apoptotic process [IDA]
- blood vessel development [TAS]
- brain development [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- heart development [ISS]
- myeloid dendritic cell differentiation [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- patterning of blood vessels [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of B cell tolerance induction [ISS]
- positive regulation of NK T cell differentiation [ISS]
- positive regulation of T cell tolerance induction [ISS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tolerance induction to self antigen [ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [ISS]
- response to cholesterol [IDA]
- response to drug [IDA]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
FGFR1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- axon guidance [TAS]
- cell migration [TAS]
- chordate embryonic development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neuron migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phospholipase activity [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [NAS]
- regulation of cell differentiation [TAS]
- skeletal system development [TAS]
- skeletal system morphogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.803882014 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.803882014, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TGFBR2 FGFR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9462 | BioGRID | 1182745 | |
| TGFBR2 FGFR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8262 | BioGRID | 2266355 |
Curated By
- BioGRID