TFAP2A
Gene Ontology Biological Process
- bone morphogenesis [ISS]
- cellular response to iron ion [IDA]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic forelimb morphogenesis [ISS]
- eyelid development in camera-type eye [ISS]
- inner ear morphogenesis [IMP]
- kidney development [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription by competitive promoter binding [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oculomotor nerve formation [ISS]
- optic cup structural organization [ISS]
- optic vesicle morphogenesis [ISS]
- palate development [IMP]
- positive regulation of bone mineralization [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of tooth mineralization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of cell differentiation [IDA]
- retina layer formation [IEP]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [IDA]
- trigeminal nerve development [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
ACOT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.993224244 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.993224244, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TFAP2A ACOT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1191785 | |
| TFAP2A ACOT1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.984 | BioGRID | 2243754 |
Curated By
- BioGRID