BAIT
LRRTM3
UNQ803/PRO1693
leucine rich repeat transmembrane neuronal 3
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
TGFBR3
BGCAN, betaglycan
transforming growth factor, beta receptor III
GO Process (22)
GO Function (11)
GO Component (6)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- cardiac epithelial to mesenchymal transition [IDA]
- cardiac muscle cell proliferation [ISS]
- cell growth [ISS]
- cell migration [ISS]
- definitive erythrocyte differentiation [ISS]
- definitive hemopoiesis [ISS]
- epithelial to mesenchymal transition [IDA]
- heart morphogenesis [ISS]
- heart trabecula formation [ISS]
- immune response [IMP]
- intracellular signal transduction [IMP]
- liver development [ISS]
- negative regulation of cellular component movement [IDA]
- negative regulation of epithelial cell proliferation [ISS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IMP]
- response to follicle-stimulating hormone [IDA]
- response to luteinizing hormone [IDA]
- response to prostaglandin E [IDA]
- transforming growth factor beta receptor signaling pathway [IDA, IMP]
- ventricular cardiac muscle tissue morphogenesis [ISS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
- PDZ domain binding [ISS]
- SMAD binding [IMP]
- coreceptor activity [IDA]
- glycosaminoglycan binding [ISS, TAS]
- heparin binding [ISS]
- protein binding [IPI]
- transforming growth factor beta binding [IDA]
- transforming growth factor beta receptor activity, type III [IDA]
- transforming growth factor beta receptor binding [ISS]
- transforming growth factor beta-activated receptor activity [IDA]
- type II transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.994790371 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.994790371, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID