BAIT
ADIPOQ
ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28
adiponectin, C1Q and collagen domain containing
GO Process (57)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- brown fat cell differentiation [ISS]
- cellular response to drug [ISS]
- cellular response to insulin stimulus [ISS]
- detection of oxidative stress [ISS]
- fatty acid beta-oxidation [ISS]
- fatty acid oxidation [ISS]
- generation of precursor metabolites and energy [TAS]
- glucose homeostasis [ISS]
- glucose metabolic process [ISS]
- low-density lipoprotein particle clearance [IDA]
- negative regulation of DNA biosynthetic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of blood pressure [IDA]
- negative regulation of cell migration [ISS]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of gluconeogenesis [ISS]
- negative regulation of granulocyte differentiation [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [ISS, NAS]
- negative regulation of intracellular protein transport [IDA]
- negative regulation of low-density lipoprotein particle receptor biosynthetic process [IDA]
- negative regulation of macrophage derived foam cell differentiation [IDA]
- negative regulation of macrophage differentiation [IDA]
- negative regulation of metanephric mesenchymal cell migration [ISS]
- negative regulation of phagocytosis [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [ISS]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of receptor binding [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of synaptic transmission [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- positive regulation of cAMP-dependent protein kinase activity [IDA]
- positive regulation of cellular protein metabolic process [IDA]
- positive regulation of cholesterol efflux [IDA]
- positive regulation of fatty acid metabolic process [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of glycogen (starch) synthase activity [ISS]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of metanephric glomerular visceral epithelial cell development [ISS]
- positive regulation of monocyte chemotactic protein-1 production [IDA]
- positive regulation of myeloid cell apoptotic process [IDA]
- positive regulation of protein kinase A signaling [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of renal albumin absorption [IDA]
- positive regulation of signal transduction [ISS]
- protein homooligomerization [ISS]
- protein localization to plasma membrane [IDA]
- regulation of glucose metabolic process [IDA]
- response to glucose [ISS]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HOMER1
HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1
homer homolog 1 (Drosophila)
GO Process (6)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.922571583 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.922571583, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID