BAIT
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
GAS6
AXLLG, AXSF
growth arrest-specific 6
GO Process (66)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- B cell chemotaxis [IDA]
- activation of protein kinase B activity [ISS]
- apoptotic cell clearance [IDA]
- blood coagulation [TAS]
- calcium ion transmembrane transport [IDA]
- cell adhesion [TAS]
- cell cycle arrest [TAS]
- cell migration [TAS]
- cell proliferation [TAS]
- cellular protein metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to glucose stimulus [ISS]
- cellular response to interferon-alpha [IDA]
- cellular response to vitamin K [IDA]
- dendritic cell differentiation [IEP]
- extracellular matrix assembly [ISS]
- fusion of virus membrane with host plasma membrane [IDA]
- hematopoietic stem cell migration to bone marrow [IDA]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of biomineral tissue development [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of dendritic cell apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [IDA]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of interferon-gamma production [IDA]
- negative regulation of interleukin-1 secretion [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-6 secretion [IDA]
- negative regulation of oligodendrocyte apoptotic process [IDA]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of renal albumin absorption [ISS]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- peptidyl-glutamic acid carboxylation [TAS]
- peptidyl-serine phosphorylation [IDA]
- phagocytosis [IDA]
- platelet activation [TAS]
- platelet aggregation [TAS]
- platelet degranulation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of TOR signaling [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of dendritic cell chemotaxis [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of natural killer cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of phagocytosis [IDA]
- positive regulation of protein export from nucleus [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IDA, ISS]
- positive regulation of protein tyrosine kinase activity [IDA]
- post-translational protein modification [TAS]
- protein kinase B signaling [IDA]
- protein phosphorylation [IDA]
- protein targeting to plasma membrane [IDA]
- proteolysis [TAS]
- receptor-mediated virion attachment to host cell [IDA]
- signal transduction [IDA, TAS]
- viral entry into host cell [IDA]
- viral genome replication [IDA]
Gene Ontology Molecular Function- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
- binding, bridging [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
- phosphatidylserine binding [IDA]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor agonist activity [IDA]
- receptor binding [IDA, IPI]
- receptor tyrosine kinase binding [IPI]
- voltage-gated calcium channel activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.828766043 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.828766043, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID