BAIT
TGM1
ARCI1, ICR2, KTG, LI, LI1, TGASE, TGK
transglutaminase 1
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNM1L
DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
dynamin 1-like
GO Process (21)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- dynamin polymerization involved in mitochondrial fission [IDA]
- membrane fission involved in mitochondrial fission [IDA]
- membrane fusion [IDA]
- mitochondrial fission [IDA, IMP]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrion morphogenesis [IMP]
- necroptotic process [IMP]
- peroxisome fission [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial fission [TAS]
- positive regulation of protein secretion [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homotetramerization [IDA]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- regulation of protein oligomerization [IDA]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.914324066 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.914324066, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID