BAIT
CXCR4
CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
chemokine (C-X-C motif) receptor 4
GO Process (16)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [TAS]
- apoptotic process [TAS]
- calcium-mediated signaling [IMP]
- cellular response to cytokine stimulus [IDA]
- chemokine-mediated signaling pathway [NAS]
- dendritic cell chemotaxis [TAS]
- entry into host cell [TAS]
- inflammatory response [TAS]
- myelin maintenance [ISS]
- positive regulation of cytosolic calcium ion concentration [TAS]
- positive regulation of oligodendrocyte differentiation [ISS]
- regulation of chemotaxis [IMP]
- response to hypoxia [IEP]
- response to virus [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EXOC1
BM-102, SEC3, SEC3L1, SEC3P, BM-012
exocyst complex component 1
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.992763477 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.992763477, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID