BAIT
SLC22A23
C6orf85, RP11-506K6.2
solute carrier family 22, member 23
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
BMP4
BMP2B, BMP2B1, MCOPS6, OFC11, ZYME
bone morphogenetic protein 4
GO Process (100)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP]
- BMP signaling pathway involved in heart induction [IMP]
- BMP signaling pathway involved in nephric duct formation [IDA]
- BMP signaling pathway involved in renal system segmentation [ISS]
- BMP signaling pathway involved in ureter morphogenesis [ISS]
- SMAD protein signal transduction [IDA]
- activation of MAPKK activity [IDA]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IDA]
- branching involved in ureteric bud morphogenesis [IDA]
- branching morphogenesis of an epithelial tube [IDA]
- bronchus development [IDA]
- bud dilation involved in lung branching [IDA]
- cardiac septum development [TAS]
- chondrocyte differentiation [ISS]
- common-partner SMAD protein phosphorylation [IDA]
- deltoid tuberosity development [ISS]
- endocardial cushion development [TAS]
- endochondral ossification [ISS]
- epithelial cell proliferation involved in lung morphogenesis [IDA]
- epithelial tube branching involved in lung morphogenesis [IDA]
- extracellular matrix organization [TAS]
- glomerular capillary formation [ISS]
- hematopoietic progenitor cell differentiation [IDA]
- intermediate mesodermal cell differentiation [IDA]
- kidney development [IMP]
- lung alveolus development [IDA]
- lung morphogenesis [IDA]
- lymphoid progenitor cell differentiation [IMP]
- macrophage differentiation [IDA]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- mesonephros development [IEP]
- metanephric collecting duct development [ISS]
- monocyte differentiation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of T cell differentiation in thymus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway [IDA]
- negative regulation of branching involved in ureteric bud morphogenesis [IDA]
- negative regulation of cell cycle [IDA]
- negative regulation of cell death [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of cell proliferation involved in heart morphogenesis [IMP]
- negative regulation of glomerular mesangial cell proliferation [IDA]
- negative regulation of glomerulus development [IDA]
- negative regulation of immature T cell proliferation in thymus [IMP]
- negative regulation of mesenchymal cell proliferation involved in ureter development [IDA]
- negative regulation of metanephric S-shaped body morphogenesis [IDA]
- negative regulation of metanephric comma-shaped body morphogenesis [IDA]
- negative regulation of mitosis [IDA]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of striated muscle tissue development [IDA]
- negative regulation of thymocyte apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- odontogenesis [IGI]
- osteoblast differentiation [IDA]
- positive chemotaxis [IDA]
- positive regulation of BMP signaling pathway [ISS]
- positive regulation of DNA-dependent DNA replication [IDA]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of branching involved in lung morphogenesis [ISS]
- positive regulation of cardiac muscle fiber development [IMP]
- positive regulation of cartilage development [IDA]
- positive regulation of cell death [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of epidermal cell differentiation [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of kidney development [IDA]
- positive regulation of ossification [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IDA]
- protein localization to nucleus [IDA]
- pulmonary artery endothelial tube morphogenesis [IDA]
- regulation of cell fate commitment [IDA]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- regulation of protein import into nucleus [IDA]
- renal system development [IEP]
- secondary heart field specification [IMP]
- smooth muscle tissue development [ISS]
- smoothened signaling pathway [IEP]
- specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway [IDA]
- steroid hormone mediated signaling pathway [IMP]
- telencephalon development [IDA]
- tendon cell differentiation [ISS]
- trachea development [IDA]
- type B pancreatic cell development [IDA]
- ureter epithelial cell differentiation [ISS]
- ureter smooth muscle cell differentiation [ISS]
- ureteric bud development [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.99993406 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.99993406, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC22A23 BMP4 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9995 | BioGRID | 2230214 |
Curated By
- BioGRID