BAIT
UGT1A1
BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT 1-1, UGT1, UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1
GO Process (20)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- bilirubin conjugation [TAS]
- cellular glucuronidation [IDA, NAS, TAS]
- cellular response to hormone stimulus [IBA]
- digestion [NAS]
- drug metabolic process [IC]
- estrogen metabolic process [TAS]
- flavone metabolic process [IDA]
- flavonoid biosynthetic process [IBA]
- flavonoid glucuronidation [IDA]
- heme catabolic process [TAS]
- heterocycle metabolic process [IC]
- negative regulation of catalytic activity [IDA]
- negative regulation of cellular glucuronidation [IDA]
- negative regulation of steroid metabolic process [IC]
- porphyrin-containing compound metabolic process [TAS]
- retinoic acid metabolic process [IC]
- small molecule metabolic process [TAS]
- steroid metabolic process [IC]
- xenobiotic glucuronidation [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DPYSL3
CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1
dihydropyrimidinase-like 3
GO Process (10)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- actin crosslink formation [ISS]
- actin filament bundle assembly [ISS]
- axon guidance [TAS]
- cellular response to cytokine stimulus [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of neuron projection development [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of neuron projection development [ISS]
- protein homooligomerization [ISS]
- response to axon injury [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.998537635 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.998537635, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID