BAIT
C1QA
complement component 1, q subcomponent, A chain
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ENPP1
ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
GO Process (21)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process [IDA]
- ATP catabolic process [ISS]
- cellular phosphate ion homeostasis [IDA]
- cellular response to insulin stimulus [IDA]
- generation of precursor metabolites and energy [IDA]
- inorganic diphosphate transport [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of glucose import [IDA]
- negative regulation of glycogen biosynthetic process [IDA]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of protein autophosphorylation [IDA]
- nucleic acid phosphodiester bond hydrolysis [ISS]
- nucleoside triphosphate catabolic process [IDA]
- phosphate-containing compound metabolic process [IDA]
- regulation of bone mineralization [IC]
- riboflavin metabolic process [TAS]
- sequestering of triglyceride [IDA]
- small molecule metabolic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function- 3'-phosphoadenosine 5'-phosphosulfate binding [IC]
- ATP binding [IDA]
- calcium ion binding [ISS]
- insulin receptor binding [IDA]
- nucleoside-triphosphate diphosphatase activity [IDA]
- nucleotide diphosphatase activity [IDA, TAS]
- phosphodiesterase I activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [ISS]
- 3'-phosphoadenosine 5'-phosphosulfate binding [IC]
- ATP binding [IDA]
- calcium ion binding [ISS]
- insulin receptor binding [IDA]
- nucleoside-triphosphate diphosphatase activity [IDA]
- nucleotide diphosphatase activity [IDA, TAS]
- phosphodiesterase I activity [ISS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- zinc ion binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.781570345 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.781570345, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID