OLFM2
Gene Ontology Biological Process
Gene Ontology Cellular Component
BMP7
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- SMAD protein signal transduction [IDA]
- cellular response to hypoxia [ISS]
- dendrite development [TAS]
- epithelial to mesenchymal transition [TAS]
- extracellular matrix organization [TAS]
- mesenchymal cell differentiation [IDA]
- mesenchyme development [ISS]
- mesonephros development [IEP]
- metanephros development [IEP]
- monocyte aggregation [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of NF-kappaB import into nucleus [ISS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell cycle [IDA]
- negative regulation of cell death [IDA]
- negative regulation of glomerular mesangial cell proliferation [IDA]
- negative regulation of mitosis [IDA]
- negative regulation of neuron differentiation [IDA]
- negative regulation of phosphorylation [IDA]
- negative regulation of striated muscle cell apoptotic process [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- neuron projection morphogenesis [IDA]
- positive regulation of bone mineralization [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of heterotypic cell-cell adhesion [IDA]
- positive regulation of hyaluranon cable assembly [IDA]
- positive regulation of osteoblast differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, TAS]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IDA]
- regulation of apoptotic process [IBA]
- regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- regulation of removal of superoxide radicals [ISS]
- skeletal system development [TAS]
- steroid hormone mediated signaling pathway [IMP]
- ureteric bud development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.898650253 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.898650253, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OLFM2 BMP7 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.921 | BioGRID | 2256278 |
Curated By
- BioGRID