BAIT
CCL3
G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3
chemokine (C-C motif) ligand 3
GO Process (52)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [IEP, IMP]
- T cell chemotaxis [IDA]
- astrocyte cell migration [ISS]
- behavior [IDA]
- calcium ion transport [IDA]
- calcium-mediated signaling [IDA]
- cell activation [IDA]
- cell-cell signaling [IDA]
- cellular calcium ion homeostasis [IDA]
- cellular response to interferon-gamma [IEP]
- cellular response to interleukin-1 [IEP]
- cellular response to organic cyclic compound [IDA]
- cellular response to tumor necrosis factor [IEP]
- chemotaxis [IDA]
- cytoskeleton organization [IDA]
- eosinophil chemotaxis [IDA]
- eosinophil degranulation [IDA]
- exocytosis [IDA]
- granulocyte chemotaxis [IDA]
- inflammatory response [IDA]
- lipopolysaccharide-mediated signaling pathway [IDA]
- lymphocyte chemotaxis [IDA]
- macrophage chemotaxis [ISS]
- monocyte chemotaxis [IC, IDA]
- negative regulation by host of viral transcription [IDA]
- negative regulation of bone mineralization [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of osteoclast differentiation [IDA]
- neutrophil chemotaxis [IDA]
- osteoblast differentiation [IEP]
- positive chemotaxis [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of calcium ion import [TAS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of catalytic activity [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of inflammatory response [ISS]
- positive regulation of interleukin-1 beta secretion [ISS]
- positive regulation of natural killer cell chemotaxis [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein kinase B signaling [IEP]
- positive regulation of tumor necrosis factor production [ISS]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IDA]
- regulation of sensory perception of pain [IDA]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- response to cholesterol [IDA]
- response to toxic substance [IDA]
- signaling [IEP]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
- CCR1 chemokine receptor binding [IPI]
- CCR5 chemokine receptor binding [IPI]
- calcium-dependent protein kinase C activity [IDA]
- chemoattractant activity [IDA]
- chemokine activity [IDA]
- identical protein binding [IPI]
- kinase activity [IDA]
- phospholipase activator activity [IDA]
- protein binding [IPI]
- protein kinase activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
VEZT
VEZATIN
vezatin, adherens junctions transmembrane protein
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.975561362 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.975561362, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID