BAIT
KCNH2
ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1
potassium voltage-gated channel, subfamily H (eag-related), member 2
GO Process (19)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cellular response to drug [IDA]
- membrane depolarization during action potential [IDA]
- membrane repolarization during action potential [IDA]
- membrane repolarization during cardiac muscle cell action potential [IMP]
- negative regulation of potassium ion export [IDA]
- negative regulation of potassium ion transmembrane transport [IDA]
- positive regulation of potassium ion transmembrane transport [IDA]
- potassium ion export [IDA]
- potassium ion homeostasis [IDA]
- potassium ion transmembrane transport [IDA]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of heart rate by hormone [TAS]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [IDA]
- regulation of potassium ion transmembrane transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [IMP]
- synaptic transmission [TAS]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- delayed rectifier potassium channel activity [IDA]
- identical protein binding [IPI]
- inward rectifier potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
- delayed rectifier potassium channel activity [IDA]
- identical protein binding [IPI]
- inward rectifier potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- voltage-gated potassium channel activity [IDA]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [IMP]
Gene Ontology Cellular Component
Homo sapiens
PREY
MIB2
ZZANK1, ZZZ5, RP11-345P4.1
mindbomb E3 ubiquitin protein ligase 2
GO Process (2)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.999999681 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999999681, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID