BAIT
CCL19
CKb11, ELC, MIP-3b, MIP3B, SCYA19, RP11-195F19.11-003
chemokine (C-C motif) ligand 19
GO Process (40)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- T cell costimulation [ISS]
- activation of JUN kinase activity [ISS]
- cell communication [TAS]
- cell maturation [ISS]
- cellular calcium ion homeostasis [TAS]
- dendritic cell chemotaxis [IDA]
- establishment of T cell polarity [IDA]
- immunological synapse formation [ISS]
- inflammatory response [NAS]
- interleukin-12 secretion [ISS]
- mature conventional dendritic cell differentiation [ISS]
- myeloid dendritic cell chemotaxis [IDA]
- negative regulation of leukocyte apoptotic process [IDA]
- positive regulation of Cdc42 GTPase activity [ISS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of Ras GTPase activity [ISS]
- positive regulation of T cell proliferation [ISS]
- positive regulation of T-helper 1 cell differentiation [ISS]
- positive regulation of cell motility [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of dendritic cell dendrite assembly [ISS]
- positive regulation of endocytosis [ISS]
- positive regulation of glycoprotein biosynthetic process [ISS]
- positive regulation of interleukin-1 beta secretion [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of receptor-mediated endocytosis [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- regulation of cell projection assembly [ISS]
- release of sequestered calcium ion into cytosol [IDA]
- response to nitric oxide [IDA]
- response to prostaglandin E [IDA]
- response to virus [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SUSD1
RP11-4O1.1
sushi domain containing 1
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.776832534 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.776832534, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID