FGFR2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- angiogenesis [ISS]
- axonogenesis [ISS]
- bone development [ISS]
- bone mineralization [ISS]
- bone morphogenesis [ISS]
- branch elongation involved in salivary gland morphogenesis [ISS]
- branching involved in labyrinthine layer morphogenesis [ISS]
- branching involved in prostate gland morphogenesis [ISS]
- branching involved in salivary gland morphogenesis [ISS]
- branching morphogenesis of a nerve [ISS]
- bud elongation involved in lung branching [ISS]
- cell fate commitment [ISS]
- cell-cell signaling [ISS]
- digestive tract development [ISS]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digestive tract morphogenesis [ISS]
- embryonic organ development [ISS]
- embryonic organ morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- epidermis morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- epithelial cell proliferation involved in salivary gland morphogenesis [ISS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- fibroblast growth factor receptor signaling pathway involved in hemopoiesis [ISS]
- fibroblast growth factor receptor signaling pathway involved in mammary gland specification [ISS]
- fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow [ISS]
- fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development [ISS]
- fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow [ISS]
- gland morphogenesis [ISS]
- hair follicle morphogenesis [ISS]
- in utero embryonic development [ISS]
- innate immune response [TAS]
- inner ear morphogenesis [ISS]
- insulin receptor signaling pathway [TAS]
- lacrimal gland development [ISS]
- lateral sprouting from an epithelium [ISS]
- limb bud formation [ISS]
- lung alveolus development [ISS]
- lung development [ISS]
- lung lobe morphogenesis [ISS]
- lung-associated mesenchyme development [ISS]
- mammary gland bud formation [ISS]
- membranous septum morphogenesis [ISS]
- mesenchymal cell differentiation [ISS]
- mesenchymal cell differentiation involved in lung development [ISS]
- mesenchymal cell proliferation involved in lung development [ISS]
- midbrain development [ISS]
- morphogenesis of embryonic epithelium [ISS]
- multicellular organism growth [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis [ISS]
- orbitofrontal cortex development [ISS]
- organ growth [ISS]
- organ morphogenesis [ISS]
- otic vesicle formation [ISS]
- outflow tract septum morphogenesis [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IMP]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell cycle [ISS]
- positive regulation of cell division [ISS]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [ISS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of phospholipase activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- post-embryonic development [ISS]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [ISS]
- prostate epithelial cord elongation [ISS]
- prostate gland morphogenesis [ISS]
- protein autophosphorylation [IDA]
- pyramidal neuron development [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of branching involved in prostate gland morphogenesis [ISS]
- regulation of cell fate commitment [ISS]
- regulation of fibroblast growth factor receptor signaling pathway [ISS]
- regulation of morphogenesis of a branching structure [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of osteoblast differentiation [TAS]
- regulation of osteoblast proliferation [TAS]
- regulation of smooth muscle cell differentiation [ISS]
- regulation of smoothened signaling pathway [ISS]
- reproductive structure development [ISS]
- skeletal system morphogenesis [TAS]
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [ISS]
- ureteric bud development [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular zone neuroblast division [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FGFR1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MAPK cascade [TAS]
- axon guidance [TAS]
- cell migration [TAS]
- chordate embryonic development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [IDA, IGI, IPI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- neuron migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IDA, IGI, IMP]
- positive regulation of neuron differentiation [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [TAS]
- positive regulation of phospholipase C activity [IDA]
- positive regulation of phospholipase activity [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [NAS]
- regulation of cell differentiation [TAS]
- skeletal system development [TAS]
- skeletal system morphogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.999999626 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999999626, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FGFR2 FGFR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2218911 | |
| FGFR2 FGFR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3300575 | |
| FGFR1 FGFR2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3490560 | |
| FGFR2 FGFR1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0 | BioGRID | 3511005 | |
| FGFR2 FGFR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID