THBS2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
THBS1
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- behavioral response to pain [IMP]
- blood vessel morphogenesis [IGI]
- cell cycle arrest [ISO]
- cell migration [ISO]
- cellular response to nitric oxide [IMP]
- endocardial cushion development [IGI]
- engulfment of apoptotic cell [ISO]
- growth plate cartilage development [IGI, IMP]
- inflammatory response [IMP]
- negative regulation of angiogenesis [IDA, IMP, ISO]
- negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of blood vessel endothelial cell migration [ISO]
- negative regulation of cGMP-mediated signaling [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of dendritic cell antigen processing and presentation [ISO]
- negative regulation of endothelial cell chemotaxis [ISO]
- negative regulation of endothelial cell migration [ISO]
- negative regulation of endothelial cell proliferation [IMP, ISO]
- negative regulation of fibrinolysis [ISO]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISO]
- negative regulation of interleukin-12 production [ISO]
- negative regulation of nitric oxide mediated signal transduction [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of plasminogen activation [ISO]
- outflow tract morphogenesis [IGI]
- peptide cross-linking [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood coagulation [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell-substrate adhesion [IDA]
- positive regulation of chemotaxis [ISO]
- positive regulation of endothelial cell apoptotic process [ISO]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of fibroblast migration [ISO]
- positive regulation of macrophage activation [ISO]
- positive regulation of macrophage chemotaxis [IMP]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of transforming growth factor beta production [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IMP, ISO]
- positive regulation of translation [ISO]
- positive regulation of tumor necrosis factor biosynthetic process [ISO]
- regulation of cGMP metabolic process [ISO]
- response to calcium ion [ISO]
- response to endoplasmic reticulum stress [IMP]
- response to glucose [ISO]
- response to magnesium ion [ISO]
- response to mechanical stimulus [ISO]
- sprouting angiogenesis [ISO]
Gene Ontology Molecular Function- collagen V binding [ISO]
- extracellular matrix binding [IDA]
- fibrinogen binding [ISO]
- fibroblast growth factor binding [ISO]
- fibronectin binding [ISO]
- heparin binding [ISO]
- integrin binding [ISO]
- laminin binding [ISO]
- low-density lipoprotein particle binding [ISO]
- phosphatidylserine binding [ISO]
- protein binding [IPI]
- transforming growth factor beta binding [ISO]
- collagen V binding [ISO]
- extracellular matrix binding [IDA]
- fibrinogen binding [ISO]
- fibroblast growth factor binding [ISO]
- fibronectin binding [ISO]
- heparin binding [ISO]
- integrin binding [ISO]
- laminin binding [ISO]
- low-density lipoprotein particle binding [ISO]
- phosphatidylserine binding [ISO]
- protein binding [IPI]
- transforming growth factor beta binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.
There exist two distinct thrombospondin molecules (designated TSP1 and TSP2) which are encoded by separate genes. TSP1 is a trimeric cell surface and extracellular matrix molecule. Sequence comparison reveals that the 2 cysteines involved in interchain disulfide linkage and trimer assembly in TSP1 are conserved in TSP2 (Laherty, C. D., O'Rourke, K., Wolf, F. W., Katz, R., Seldin, M. F., ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| THBS1 THBS2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID