CASP8
Gene Ontology Biological Process
- B cell activation [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell activation [TAS]
- TRAIL-activated apoptotic signaling pathway [IDA]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [IGI, IMP, TAS]
- apoptotic signaling pathway [IMP, TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to mechanical stimulus [IEP]
- execution phase of apoptosis [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IBA]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- macrophage differentiation [TAS]
- natural killer cell activation [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP, IMP]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- response to tumor necrosis factor [IMP]
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- cysteine-type peptidase activity [TAS]
- death effector domain binding [IPI]
- peptidase activity [IMP]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- cysteine-type peptidase activity [TAS]
- death effector domain binding [IPI]
- peptidase activity [IMP]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
DEDD2
Gene Ontology Biological Process
- RNA processing [NAS]
- apoptotic nuclear changes [IDA]
- cellular homeostasis [NAS]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- intracellular signal transduction [NAS]
- negative regulation of transcription, DNA-templated [NAS]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- rRNA catabolic process [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DEDD and DEDD2 associate with caspase-8/10 and signal cell death.
An apoptotic signal triggered by cell surface death receptors is disseminated to intracellular compartments through protein-protein interactions mediated by conserved domains such as the death effector domain (DED). A unique family of single DED-containing proteins, including DEDD and DEDD2, is targeted to the nucleolus. However, the role of DEDD/DEDD2 in apoptosis remains less understood. Here we show that DEDD and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DEDD2 CASP8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DEDD2 CASP8 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID