LPAR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLC9A1
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cell migration [TAS]
- cellular response to acidic pH [IDA, ISS]
- cellular response to epinephrine stimulus [IMP]
- cellular response to mechanical stimulus [TAS]
- cellular sodium ion homeostasis [IDA]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan catabolic process [TAS]
- hyaluronan metabolic process [TAS]
- hydrogen ion transmembrane transport [IDA]
- ion transport [TAS]
- maintenance of cell polarity [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of calcium:sodium antiporter activity [IMP]
- positive regulation of cardiac muscle hypertrophy [IMP]
- positive regulation of the force of heart contraction [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein oligomerization [ISS]
- regulation of cardiac muscle cell membrane potential [TAS]
- regulation of cardiac muscle contraction by calcium ion signaling [IMP]
- regulation of focal adhesion assembly [TAS]
- regulation of intracellular pH [IDA]
- regulation of pH [IDA, TAS]
- regulation of stress fiber assembly [TAS]
- regulation of the force of heart contraction by cardiac conduction [IMP]
- response to acidic pH [IDA]
- response to muscle stretch [IMP]
- small molecule metabolic process [TAS]
- sodium ion export [ISS]
- sodium ion import across plasma membrane [IDA]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- calcium-dependent protein binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [TAS]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein complex scaffold [TAS]
- protein phosphatase 2B binding [IDA, IPI]
- sodium:proton antiporter activity [IDA, ISS]
- sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [TAS]
- solute:proton antiporter activity [TAS]
- calcium-dependent protein binding [IDA]
- phosphatidylinositol-4,5-bisphosphate binding [TAS]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein complex scaffold [TAS]
- protein phosphatase 2B binding [IDA, IPI]
- sodium:proton antiporter activity [IDA, ISS]
- sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential [TAS]
- solute:proton antiporter activity [TAS]
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Quantitative Score
- 0.999984453 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 3.0 HEK 293T cells CompPASS score = 0.999984453, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HEK293T.
- BioPlex HCT HCT116 cells CompPASS score = 0.999999996, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
- This data may be re-scored from BioPlex 1.0 (PMID: 26186194) and BioPlex 2.0 (PMID: 28514442). Only scores from within the same cell line in BioPlex 3.0 (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LPAR1 SLC9A1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 1195183 | |
| LPAR1 SLC9A1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9999 | BioGRID | 2226328 |
Curated By
- BioGRID