BCL2L11
Gene Ontology Biological Process
- B cell apoptotic process [IGI]
- B cell homeostasis [IGI, IMP]
- T cell homeostasis [IGI, IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- apoptotic process involved in embryonic digit morphogenesis [IGI]
- cell-matrix adhesion [IMP]
- cellular process regulating host cell cycle in response to virus [IDA]
- developmental pigmentation [IGI]
- ear development [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI, IMP]
- in utero embryonic development [IGI]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, ISO]
- kidney development [IGI]
- leukocyte homeostasis [IGI, IMP]
- lymphocyte homeostasis [IGI, IMP]
- male gonad development [IGI]
- mammary gland development [IMP]
- myeloid cell homeostasis [IGI]
- odontogenesis of dentin-containing tooth [IGI]
- positive regulation of apoptotic process [IGI, IMP, ISO]
- positive regulation of apoptotic process by virus [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of cell death [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of fibroblast apoptotic process [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial membrane permeability involved in apoptotic process [IGI]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein homooligomerization [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- post-embryonic development [IGI]
- post-embryonic organ morphogenesis [IMP]
- regulation of apoptotic process [IGI]
- regulation of developmental pigmentation [IGI]
- regulation of organ growth [IMP]
- response to endoplasmic reticulum stress [IDA, ISO]
- spermatogenesis [IGI]
- spleen development [IGI]
- thymocyte apoptotic process [IGI]
- thymus development [IGI]
- tube formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DYNLL1
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- actin cytoskeleton organization [TAS]
- anatomical structure morphogenesis [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- apoptotic process [TAS]
- female gamete generation [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic cell cycle [TAS]
- negative regulation of phosphorylation [IDA]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- substantia nigra development [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent inducers of apoptosis, and some appear to play a critical role in developmentally programmed cell death. We examined the regulation of the proapoptotic activity of the BH3-only protein Bim. In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DYNLL1 BCL2L11 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DYNLL1 BCL2L11 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
| BCL2L11 DYNLL1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| DYNLL1 BCL2L11 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID