BAIT
EREG
ER
epiregulin
GO Process (37)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of MAPK activity [IBA]
- anatomical structure morphogenesis [TAS]
- cell-cell signaling [IDA]
- cytokine-mediated signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IBA, ISS, TAS]
- female meiotic division [ISS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- keratinocyte differentiation [TAS]
- keratinocyte proliferation [IDA]
- luteinizing hormone signaling pathway [ISS]
- mRNA transcription [IDA]
- negative regulation of cell proliferation [ISS]
- negative regulation of epithelial cell proliferation [TAS]
- negative regulation of smooth muscle cell differentiation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- oocyte maturation [ISS]
- organ morphogenesis [TAS]
- ovarian cumulus expansion [ISS]
- ovulation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of DNA replication [IDA, ISS]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of cytokine biosynthetic process [IDA]
- positive regulation of cytokine production [ISS]
- positive regulation of epidermal growth factor-activated receptor activity [ISS]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of innate immune response [ISS]
- positive regulation of interleukin-6 biosynthetic process [ISS]
- positive regulation of mitosis [ISS]
- positive regulation of phosphorylation [IDA, ISS]
- positive regulation of protein kinase activity [IDA]
- positive regulation of smooth muscle cell proliferation [ISS]
- primary follicle stage [ISS]
- wound healing [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ERBB4
ALS19, HER4, p180erbB4
erb-b2 receptor tyrosine kinase 4
GO Process (34)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac muscle tissue regeneration [ISS]
- cell migration [IDA]
- cell proliferation [TAS]
- central nervous system morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- lactation [IMP]
- mammary gland alveolus development [ISS]
- mammary gland epithelial cell differentiation [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- nervous system development [ISS]
- neural crest cell migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- olfactory bulb interneuron differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of STAT protein import into nucleus [IMP]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell migration [ISS]
- signal transduction [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4.
Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling. We investigated the binding ability of epiregulin to four ErbB family receptors using ... [more]
Oncogene Dec. 04, 1997; 15(23);2841-8 [Pubmed: 9419975]
Throughput
- Low Throughput
Curated By
- BioGRID