BAIT
PLCG1
NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, RP3-511B24.2
phospholipase C, gamma 1
GO Process (23)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell receptor signaling pathway [TAS]
- activation of MAPKK activity [TAS]
- activation of phospholipase C activity [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- calcium-mediated signaling [IMP]
- cell migration [IMP]
- cellular response to epidermal growth factor stimulus [IDA, IMP]
- cytokine-mediated signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [IMP, TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- inositol phosphate metabolic process [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of angiogenesis [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of epithelial cell migration [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- signal transduction [NAS, TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GAB2
GRB2-associated binding protein 2
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- innate immune response [TAS]
- osteoclast differentiation [IMP]
- phosphatidylinositol-mediated signaling [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of mast cell degranulation [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.
We describe a novel human adapter molecule containing a pleckstrin homolgy (PH) domain at the N terminus that is closely related to human Grb2-associated binder 1, Gab1, and Drosophila daughter of sevenless. We designate this protein as Gab2. Northern blot analysis indicates that Gab2 is widely expressed and has an overlapping but distinctive expression pattern as compared with Gab1, with ... [more]
J. Biol. Chem. Jul. 09, 1999; 274(28);19649-54 [Pubmed: 10391903]
Throughput
- Low Throughput
Curated By
- BioGRID