MAML2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAML1
Gene Ontology Biological Process
- Notch signaling pathway [IDA, TAS]
- atrioventricular node cell development [ISS]
- atrioventricular node development [ISS]
- gene expression [TAS]
- positive regulation of myotube differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein phosphorylation [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.
The molecular mechanisms by which Notch receptors induce diverse biological responses are not fully understood. We recently cloned a mammalian homologue of the Mastermind gene of Drosophila melanogaster, MAML1 (Mastermind-like-1 molecule) and determined that it functions as a transcriptional coactivator for Notch receptors. In this report, we characterize two additional genes in this Mastermind-like gene family: MAML2 and MAML3. The ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID