TAF1B
Gene Ontology Biological Process
- RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript [IDA]
- gene expression [TAS]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- RNA polymerase I CORE element sequence-specific DNA binding [IDA]
- RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity [IDA]
- TBP-class protein binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- RNA polymerase I CORE element sequence-specific DNA binding [IDA]
- RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity [IDA]
- TBP-class protein binding [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
Gene Ontology Cellular Component
UBTF
Gene Ontology Biological Process
- chromatin remodeling [IBA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase I promoter [ISS]
- regulation of transcription from RNA polymerase I promoter [TAS]
- regulation of transcription, DNA-templated [IBA]
- termination of RNA polymerase I transcription [TAS]
- transcription elongation from RNA polymerase I promoter [TAS]
- transcription from RNA polymerase I promoter [TAS]
- transcription initiation from RNA polymerase I promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleolus [IDA, ISS]
- nucleoplasm [TAS]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Repression of RNA polymerase I transcription by the tumor suppressor p53.
The tumor suppressor protein p53 is frequently inactivated in tumors. It functions as a transcriptional activator as well as a repressor for a number of viral and cellular promoters transcribed by RNA polymerase II (Pol II) and by RNA Pol III. Moreover, it appears that p53 also suppresses RNA Pol I transcription. In this study, we examined the molecular mechanism ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID