Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.

Publication

Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.

Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH

Phosphoinositide kinases play central roles in signal transduction by phosphorylating the inositol ring at specific positions. The structure of one such enzyme, type IIbeta phosphatidylinositol phosphate kinase, reveals a protein kinase ATP-binding core and demonstrates that all phosphoinositide kinases belong to one superfamily. The enzyme is a disc-shaped homodimer with a 33 x 48 A basic flat face that suggests ... [more]

Cell Sep. 18, 1998; 94(6);829-39 [Pubmed: 9753329]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PIP4K2B

Gene Ontology Biological Process

Gene Ontology Molecular Function

1-phosphatidylinositol-4-phosphate 5-kinase activity [IDA]receptor signaling protein activity [TAS]

Gene Ontology Cellular Component