BAIT
AQP1
AQP-CHIP, CHIP28, CO
aquaporin 1 (Colton blood group)
GO Process (46)
GO Function (12)
GO Component (15)
Gene Ontology Biological Process
- ammonium transmembrane transport [IDA]
- ammonium transport [IDA]
- bicarbonate transport [TAS]
- cGMP biosynthetic process [IDA]
- carbon dioxide transmembrane transport [IDA]
- carbon dioxide transport [IDA]
- cation transmembrane transport [IDA]
- cell volume homeostasis [IMP]
- cellular homeostasis [IDA]
- cellular hyperosmotic response [IMP]
- cellular response to UV [IDA]
- cellular response to cAMP [IDA, IEP]
- cellular response to copper ion [IDA]
- cellular response to dexamethasone stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to hypoxia [IDA]
- cellular response to inorganic substance [IDA]
- cellular response to mechanical stimulus [IDA]
- cellular response to mercury ion [IDA]
- cellular response to nitric oxide [IDA]
- cellular response to retinoic acid [IDA]
- cellular response to salt stress [IDA]
- cellular response to stress [IDA]
- cellular water homeostasis [IBA]
- cerebrospinal fluid secretion [IEP]
- establishment or maintenance of actin cytoskeleton polarity [IMP]
- glycerol transport [IDA]
- lateral ventricle development [IEP]
- maintenance of symbiont-containing vacuole by host [IMP]
- multicellular organismal water homeostasis [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- nitric oxide transport [IDA]
- odontogenesis [IEP]
- pancreatic juice secretion [IEP]
- positive regulation of angiogenesis [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of saliva secretion [IMP]
- potassium ion transmembrane transport [IMP, ISS]
- potassium ion transport [ISS]
- renal water transport [IDA]
- response to drug [IDA]
- small molecule metabolic process [TAS]
- transepithelial water transport [IDA]
- transmembrane transport [TAS]
- water transport [IDA, IMP, TAS]
Gene Ontology Molecular Function- ammonium transmembrane transporter activity [IDA]
- carbon dioxide transmembrane transporter activity [IDA, TAS]
- glycerol channel activity [IBA]
- glycerol transmembrane transporter activity [IDA]
- intracellular cGMP activated cation channel activity [IDA]
- nitric oxide transmembrane transporter activity [IDA]
- potassium channel activity [IMP]
- potassium ion transmembrane transporter activity [ISS]
- protein binding [IPI]
- transmembrane transporter activity [IDA]
- water channel activity [EXP, IDA, IMP]
- water transmembrane transporter activity [IDA]
- ammonium transmembrane transporter activity [IDA]
- carbon dioxide transmembrane transporter activity [IDA, TAS]
- glycerol channel activity [IBA]
- glycerol transmembrane transporter activity [IDA]
- intracellular cGMP activated cation channel activity [IDA]
- nitric oxide transmembrane transporter activity [IDA]
- potassium channel activity [IMP]
- potassium ion transmembrane transporter activity [ISS]
- protein binding [IPI]
- transmembrane transporter activity [IDA]
- water channel activity [EXP, IDA, IMP]
- water transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border [IDA]
- brush border membrane [IDA]
- cytoplasm [IDA]
- extracellular vesicular exosome [IDA]
- integral component of plasma membrane [TAS]
- nuclear membrane [IDA]
- nucleus [IDA]
- plasma membrane [IDA, TAS]
- sarcolemma [IDA]
- symbiont-containing vacuole [ISS]
- symbiont-containing vacuole membrane [IDA]
Homo sapiens
PREY
ATP6V0A2
A2, ARCL, ARCL2A, ATP6A2, ATP6N1D, J6B7, RTF, STV1, TJ6, TJ6M, TJ6S, VPH1, WSS
ATPase, H+ transporting, lysosomal V0 subunit a2
GO Process (10)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- ATP synthesis coupled proton transport [IBA]
- cellular iron ion homeostasis [TAS]
- immune response [TAS]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
- vacuolar acidification [IBA]
- vacuolar proton-transporting V-type ATPase complex assembly [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affinity purification of 10,128 human proteins-half the proteome-in 293T cells and includes 118,162 interactions among 14,586 proteins. The second results from 5,522 immunoprecipitations in HCT116 ... [more]
Cell May. 27, 2021; 184(11);3022-3040.e28 [Pubmed: 33961781]
Quantitative Score
- 0.995265542 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex HCT HCT116 cells CompPASS score = 0.995265542, threshold = 0.75. Quantitative scores are calculated by CompPASS-Plus (Huttlin et al. Cell 2015, PMID: 26186194). The 0.75 threshold represents the top 2% of scores in HCT116.
- Only scores from within the same cell line in BioPlex HCT (PMID: 33961781) should be compared directly. For comparison of HEK293T and HCT116 interaction networks with relaxed threshold = 0.1, see BioPlex Interactome (https://bioplex.hms.harvard.edu/index.php).
Curated By
- BioGRID