GATA2
Gene Ontology Biological Process
- blood coagulation [TAS]
- eosinophil fate commitment [IDA]
- negative regulation of Notch signaling pathway [IDA]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fat cell proliferation [IMP]
- negative regulation of neural precursor cell proliferation [IDA]
- positive regulation of angiogenesis [IDA]
- positive regulation of phagocytosis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
ZFPM1
Gene Ontology Biological Process
- T-helper cell lineage commitment [IC]
- atrial septum morphogenesis [ISS]
- atrioventricular valve morphogenesis [ISS]
- blood coagulation [TAS]
- cardiac muscle tissue morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- erythrocyte differentiation [ISS]
- heart development [IBA]
- megakaryocyte differentiation [IBA, ISS]
- mitral valve formation [ISS]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of interleukin-4 biosynthetic process [IDA]
- negative regulation of mast cell differentiation [ISS]
- negative regulation of protein binding [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- outflow tract morphogenesis [ISS]
- platelet formation [IGI]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- regulation of definitive erythrocyte differentiation [IDA, IMP]
- transcriptional activation by promoter-enhancer looping [ISS]
- tricuspid valve formation [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.
Erythroid and megakaryocytic lineage differentiation and maturation are regulated via cooperation between transcription factor GATA1 and its essential cofactor friend-of-GATA1 (FOG1). The interaction between these two murine proteins is well studied in vitro and depends on the binding of Fog1 to the N-terminal zinc finger (N-finger) of Gata1. We identified the human FOG1 gene on chromosome 16q24 and found expression ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GATA2 ZFPM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 2220574 | |
| GATA2 ZFPM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3077669 |
Curated By
- BioGRID