Publication

Binding of gelsolin domain 2 to actin. An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin.

Renoult C, Blondin L, Fattoum A, Ternent D, Maciver SK, Raynaud F, Benyamin Y, Roustan C

It is generally assumed that of the six domains that comprise gelsolin, domain 2 is primarily responsible for the initial contact with the actin filament that will ultimately result in the filament being severed. Other actin-binding regions within domains 1 and 4 are involved in gelsolin's severing and subsequent capping activity. The overall fold of all gelsolin repeated domains are ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID